Global Active Pharmaceutical Ingredients (API) Market 2021-2028

Bonafide Trust 03-04-2022 254 Pages
Region : Global Category : Lifescience Pharmaceutical

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Report Description
Table of Contents
List of Figure Tables

Global active pharmaceutical ingredients market will reach $334 billion by 2028, growing by 6.9% annually over 2021-2028, driven by rising adoption of biologics in disease management, increasing regulatory approvals, patent expiration of major drugs, growing trend of outsourcing and increase in geriatric population. Highlighted with 146 tables and 104 figures, this 254-page report “Global Active Pharmaceutical Ingredients (API) Market 2021-2028 by Synthesis (Synthetic, Biotech, HPAPI), Manufacturing Process (Captive, Merchant), Therapeutic Application, Drug Type, and Region: Trend Forecast and Growth Opportunity” is based on a comprehensive research of the entire global active pharmaceutical ingredients market and all its sub-segments through extensively detailed classifications. Profound analysis and assessment are generated from premium primary and secondary information sources with inputs derived from industry professionals across the value chain. The report is based on studies on 2018-2021 and provides forecast from 2022 till 2028 with 2021 as the base year. (Please note: The report will be updated before delivery so that the latest historical year is the base year and the forecast covers at least 5 years over the base year.) In-depth qualitative analyses include identification and investigation of the following aspects: • Market Structure • Growth Drivers • Restraints and Challenges • Emerging Product Trends & Market Opportunities • Porter’s Fiver Forces The trend and outlook of global market is forecast in optimistic, balanced, and conservative view by taking into account of COVID-19. The balanced (most likely) projection is used to quantify global active pharmaceutical ingredients market in every aspect of the classification from perspectives of Synthesis, Manufacturing Process, Therapeutic Application, Drug Type, and Region. Based on Synthesis, the global market is segmented into the following sub-markets with annual revenue ($ bn) for 2018-2028 included in each section. Synthetic API • Branded Synthetic API • Generic Synthetic API Biotech API by Drug Type: • Monoclonal Antibodies • Recombinant Proteins • Vaccines • Other Biotech APIs Biotech API by Customer Base: • Innovative Biologic API • Generic Biosimilar API Biotech API by Expression Technology: • Mammalian Expression • Microbial Expression • Yeast Expression • Insect Expression • Other Expression Technologies HPAPI • Branded HPAPI • Generic HPAPI Based on Manufacturing Process, the global market is segmented into the following sub-markets with annual revenue ($ bn) for 2018-2028 included in each section. Captive Manufacturing • Branded Captive API • Generic Captive API Merchant Manufacturing by Drug Type: • Branded Merchant API • Generic Merchant API Merchant Manufacturing by Drug Synthesis: • Merchant Synthetic API • Merchant Biotech API By Therapeutic Application, the global market is segmented into the following sub-markets with annual revenue ($ bn) for 2018-2028 included in each section. • Infectious Diseases • Oncology • Ophthalmology • Cardiovascular Disorders • Central Nervous System • Pulmonary Disorders • Orthopedics • Other Applications By Drug Type, the global market is segmented into the following sub-markets with annual revenue ($ bn) for 2018-2028 included in each section. • Branded Prescription Drugs • Generic Prescription Drugs • OTC Drugs Geographically, the following regions together with the listed national/local markets are fully investigated: • North America (U.S., Canada, and Mexico) • Europe (Germany, UK, France, Spain, Italy, Russia, Rest of Europe; Rest of Europe is further segmented into Netherlands, Switzerland, Poland, Sweden, Belgium, Austria, Ireland, Norway, Denmark, and Finland) • APAC (Japan, China, South Korea, Australia, India, and Rest of APAC; Rest of APAC is further segmented into Indonesia, Malaysia, New Zealand, Singapore, Thailand, and Vietnam) • South America (Brazil, Chile, Argentina, Rest of South America) • MEA (UAE, Saudi Arabia, South Africa, Other Nations) For each aforementioned region and country, detailed analysis and data for annual revenue ($ bn) are available for 2018-2028. The breakdown of all regional markets by country and split of key national markets by Synthesis, Manufacturing Process, and Therapeutic Application, over the forecast years are also included. The report also covers current competitive scenario and the predicted trend; and profiles key vendors including market leaders and important emerging players. Selected Key Players: AbbVie Inc. Astrazeneca Aurobindo Pharma Ltd. BASF Bayer AG Boehringer Ingelheim Catalent Inc. Dr. Reddy's Laboratories F. Hoffmann-La Roche GlaxoSmithKline plc Lonza Group Lupin Limited Merck & Co., Inc. Mylan NV Novartis International AG Pfizer Inc. Sanofi Sun Pharmaceutical Industries Ltd. Teva Pharmaceutical Industries Ltd. Thermo Fisher Scientific (Please note: The report will be updated before delivery so that the latest historical year is the base year and the forecast covers at least 5 years over the base year.)

1 Introduction 12

1.1 Industry Definition and Research Scope 12

1.1.1 Industry Definition 12

1.1.2 Research Scope 13

1.2 Research Methodology 16

1.2.1 Overview of Market Research Methodology 16

1.2.2 Market Assumption 17

1.2.3 Secondary Data 17

1.2.4 Primary Data 17

1.2.5 Data Filtration and Model Design 18

1.2.6 Market Size/Share Estimation 19

1.2.7 Research Limitations 20

1.3 Executive Summary 21

2 Market Overview and Dynamics 23

2.1 Market Size and Forecast 23

2.1.1 Impact of COVID-19 on World Economy 24

2.1.2 Impact of COVID-19 on the Market 26

2.2 Major Growth Drivers 33

2.3 Market Restraints and Challenges 41

2.4 Emerging Opportunities and Market Trends 44

2.5 Porter’s Fiver Forces Analysis 48

3 Segmentation of Global Market by Synthesis 52

3.1 Market Overview by Synthesis 52

3.2 Synthetic API 54

3.2.1 Branded Synthetic API 55

3.2.2 Generic Synthetic API 56

3.3 Biotech API 57

3.3.1 Biotech API by Drug Type 58

3.3.1.1 Monoclonal Antibodies 59

3.3.1.2 Recombinant Proteins 60

3.3.1.3 Vaccines 61

3.3.1.4 Other Biotech APIs 62

3.3.2 Biotech API by Category 63

3.3.2.1 Innovative Biologic API 64

3.3.2.2 Generic Biosimilar API 65

3.3.3 Biotech API by Expression Technology 66

3.3.3.1 Mammalian Expression 67

3.3.3.2 Microbial Expression 68

3.3.3.3 Yeast Expression 69

3.3.3.4 Insect Expression 70

3.3.3.5 Other Expression Technologies 71

3.4 HPAPI 72

3.4.1 Branded HPAPI 73

3.4.2 Generic HPAPI 74

4 Segmentation of Global Market by Manufacturing Process 75

4.1 Market Overview by Manufacturing Process 75

4.2 Captive Manufacturing 77

4.2.1 Branded Captive API 78

4.2.2 Generic Captive API 79

4.3 Merchant Manufacturing 80

4.3.1 Merchant Manufacturing by Drug Type 81

4.3.1.1 Branded Merchant API 82

4.3.1.2 Generic Merchant API 83

4.3.2 Merchant Manufacturing by Drug Synthesis 84

4.3.2.1 Merchant Synthetic API 85

4.3.2.2 Merchant Biotech API 86

5 Segmentation of Global Market by Therapeutic Application 87

5.1 Market Overview by Therapeutic Application 87

5.2 Infectious Diseases 89

5.3 Oncology 90

5.4 Ophthalmology 91

5.5 Cardiovascular Disorders 92

5.6 Central Nervous System 93

5.7 Pulmonary Disorders 94

5.8 Orthopedics 95

5.9 Other Applications 96

6 Segmentation of Global Market by Drug Type 97

6.1 Market Overview by Drug Type 97

6.2 Branded Prescription Drugs 99

6.3 Generic Prescription Drugs 100

6.4 OTC Drugs 101

7 Segmentation of Global Market by Region 102

7.1 Geographic Market Overview 2021-2028 102

7.2 North America Market 2021-2028 by Country 107

7.2.1 Overview of North America Market 107

7.2.2 U.S. 110

7.2.3 Canada 121

7.2.4 Mexico 123

7.3 European Market 2021-2028 by Country 125

7.3.1 Overview of European Market 125

7.3.2 UK 128

7.3.3 France 130

7.3.4 Germany 132

7.3.5 Spain 134

7.3.6 Italy 136

7.3.7 Russia 138

7.3.8 Rest of European Market 140

7.4 Asia-Pacific Market 2021-2028 by Country 142

7.4.1 Overview of Asia-Pacific Market 142

7.4.2 China 145

7.4.3 Japan 147

7.4.4 India 150

7.4.5 Australia 152

7.4.6 South Korea 154

7.4.7 Rest of APAC Region 156

7.5 South America Market 2021-2028 by Country 158

7.5.1 Argentina 161

7.5.2 Brazil 163

7.5.3 Chile 165

7.5.4 Rest of South America Market 167

7.6 Rest of World Market 2021-2028 by Country 168

7.6.1 UAE 171

7.6.2 Saudi Arabia 173

7.6.3 South Africa 175

7.6.4 Other National Markets 177

8 Competitive Landscape 178

8.1 Overview of Key Vendors 178

8.2 New Product Launch, Partnership, Investment, and M&A 181

8.3 Company Profiles 182

AbbVie Inc. 182

Astrazeneca 184

Aurobindo Pharma Ltd. 189

BASF 192

Bayer AG 195

Boehringer Ingelheim 199

Catalent Inc. 204

Dr. Reddy's Laboratories 207

F. Hoffmann-La Roche 209

GlaxoSmithKline plc 211

Lonza Group 216

Lupin Limited 221

Merck & Co., Inc. 224

Mylan NV 227

Novartis International AG 230

Pfizer Inc. 233

Sanofi 238

Sun Pharmaceutical Industries Ltd. 241

Teva Pharmaceutical Industries Ltd. 244

Thermo Fisher Scientific 246

9 Investing in Global Market: Risk Assessment and Management 248

9.1 Risk Evaluation of Global Market 248

9.2 Critical Success Factors (CSFs) 251

Related Reports and Products 254

List of Tables:

Table 1. Snapshot of Global Active Pharmaceutical Ingredients (API) Market in Balanced Perspective, 2021-2028 22
Table 2. World Economic Outlook, 2021-2031 25
Table 3. World Top 10 Pharmaceutical Companies Based on Projected R&D Spending in 2026, $ bn 40
Table 4. Main Product Trends and Market Opportunities in Global Active Pharmaceutical Ingredients (API) Market 44
Table 5. Global Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 52
Table 6. Global Active Pharmaceutical Ingredients (API) Market: Synthetic API by Drug Type, 2018-2028, $ bn 54
Table 7. Global Active Pharmaceutical Ingredients (API) Market: Biotech API by Drug Type, 2018-2028, $ bn 58
Table 8. Global Active Pharmaceutical Ingredients (API) Market: Biotech API by Category, 2018-2028, $ bn 63
Table 9. Global Active Pharmaceutical Ingredients (API) Market: Biotech API by Expression Technology, 2018-2028, $ bn 66
Table 10. Global Active Pharmaceutical Ingredients (API) Market: HPAPI by Drug Type, 2018-2028, $ bn 72
Table 11. Global Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 75
Table 12. Global Active Pharmaceutical Ingredients (API) Market: Captive Manufacturing by Drug Type, 2018-2028, $ bn 77
Table 13. Global Active Pharmaceutical Ingredients (API) Market: Merchant Manufacturing by Drug Type, 2018-2028, $ bn 81
Table 14. Global Active Pharmaceutical Ingredients (API) Market: Merchant Manufacturing by Drug Synthesis, 2018-2028, $ bn 84
Table 15. Global Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 87
Table 16. Global Active Pharmaceutical Ingredients (API) Market by Drug Type, 2018-2028, $ bn 97
Table 17. Global Active Pharmaceutical Ingredients (API) Market by Region, 2018-2028, $ bn 103
Table 18. World Health Spending by Region, $ bn, 2013-2020 105
Table 19. Leading National Active Pharmaceutical Ingredients (API) Market, 2021 and 2028, $ bn 106
Table 20. North America Active Pharmaceutical Ingredients (API) Market by Country, 2018-2028, $ bn 109
Table 21. U.S. Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 112
Table 22. U.S. Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 112
Table 23. U.S. Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 112
Table 24. Top 15 Countries Supplying API for Medicines Consumed in the US, 2019, % based on Dollar Value 115
Table 25. Canada Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 122
Table 26. Canada Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 122
Table 27. Canada Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 122
Table 28. Mexico Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 124
Table 29. Mexico Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 124
Table 30. Mexico Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 124
Table 31. Europe Active Pharmaceutical Ingredients (API) Market by Country, 2018-2028, $ bn 127
Table 32. UK Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 129
Table 33. UK Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 129
Table 34. UK Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 129
Table 35. France Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 131
Table 36. France Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 131
Table 37. France Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 131
Table 38. Germany Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 133
Table 39. Germany Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 133
Table 40. Germany Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 133
Table 41. Spain Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 135
Table 42. Spain Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 135
Table 43. Spain Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 135
Table 44. Italy Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 137
Table 45. Italy Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 137
Table 46. Italy Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 137
Table 47. Russia Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 139
Table 48. Russia Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 139
Table 49. Russia Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 139
Table 50. Active Pharmaceutical Ingredients (API) Market in Rest of Europe by Country, 2018-2028, $ bn 141
Table 51. APAC Active Pharmaceutical Ingredients (API) Market by Country, 2018-2028, $ bn 144
Table 52. China Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 146
Table 53. China Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 146
Table 54. China Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 146
Table 55. Japan Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 149
Table 56. Japan Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 149
Table 57. Japan Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 149
Table 58. India Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 151
Table 59. India Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 151
Table 60. India Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 151
Table 61. Australia Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 153
Table 62. Australia Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 153
Table 63. Australia Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 153
Table 64. South Korea Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 155
Table 65. South Korea Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 155
Table 66. South Korea Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 155
Table 67. Active Pharmaceutical Ingredients (API) Market in Rest of APAC by Country, 2018-2028, $ bn 157
Table 68. South America Active Pharmaceutical Ingredients (API) Market by Country, 2018-2028, $ bn 160
Table 69. Argentina Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 162
Table 70. Argentina Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 162
Table 71. Argentina Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 162
Table 72. Brazil Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 164
Table 73. Brazil Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 164
Table 74. Brazil Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 164
Table 75. Chile Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 166
Table 76. Chile Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 166
Table 77. Chile Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 166
Table 78. RoW Active Pharmaceutical Ingredients (API) Market by Country, 2018-2028, $ bn 170
Table 79. UAE Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 172
Table 80. UAE Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 172
Table 81. UAE Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 172
Table 82. Saudi Arabia Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 174
Table 83. Saudi Arabia Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 174
Table 84. Saudi Arabia Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 174
Table 85. South Africa Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 176
Table 86. South Africa Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 176
Table 87. South Africa Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 176
Table 88. AbbVie Inc.: Company Snapshot 182
Table 89. AbbVie Inc.: Product Portfolio 182
Table 90. AbbVie Inc.: Revenue, 2018-2020, $ bn 183
Table 91. Astrazeneca: Company Snapshot 184
Table 92. Astrazeneca: Revenue, 2018-2020, $ bn 185
Table 93. Aurobindo Pharma Ltd.: Company Snapshot 189
Table 94. Aurobindo Pharma Ltd.: Product Portfolio 190
Table 95. BASF: Company Snapshot 192
Table 96. BASF: Business Segmentation 193
Table 97. BASF: Revenue by Region 193
Table 98. Bayer AG: Company Snapshot 195
Table 99. Bayer AG: Business Segmentation 196
Table 100. Bayer AG: Revenue, 2018-2020, € bn 196
Table 101. Boehringer Ingelheim: Company Snapshot 199
Table 102. Boehringer Ingelheim: Business Segmentation in 2019 200
Table 103. Boehringer Ingelheim: Product Portfolio 200
Table 104. Boehringer Ingelheim: Revenue, 2018-2020, EUR billion 201
Table 105. Boehringer Ingelheim: Revenue by Region in 2019 201
Table 106. Catalent Inc.: Company Snapshot 204
Table 107. Catalent Inc.: Business Segmentation in 2018 205
Table 108. Catalent Inc.: Product Portfolio 205
Table 109. Catalent Inc.: Revenue, 2018-2020, $ million 206
Table 110. Catalent Inc.: Revenue by Region in 2018 206
Table 111. Dr. Reddy's Laboratories: Company Snapshot 207
Table 112. Dr. Reddy's Laboratories: Business Segmentation 207
Table 113. Dr. Reddy's Laboratories: Revenue, 2019-2021, $ bn 208
Table 114. F. Hoffmann-La Roche: Company Snapshot 209
Table 115. F. Hoffmann-La Roche: Business Segmentation 210
Table 116. GlaxoSmithKline: Company Snapshot 211
Table 117. GlaxoSmithKline: Business Segmentation 212
Table 118. GlaxoSmithKline: Product Portfolio 213
Table 119. GlaxoSmithKline: Revenue, 2018-2020, $ bn 214
Table 120. Lonza Group: Company Snapshot 216
Table 121. Lonza Group: Business Segmentation in 2018 217
Table 122. Lonza Group: Product Portfolio 217
Table 123. Lonza Group: Revenue by Region in 2018 218
Table 124. Lupin Limited: Company Snapshot 221
Table 125. Lupin Limited: Business Segmentation 221
Table 126. Merck & Co., Inc.: Company Snapshot 224
Table 127. Merck & Co., Inc.: Business Segmentation 224
Table 128. Merck & Co., Inc.: Revenue, 2018-2020, $ bn 225
Table 129. Mylan NV: Company Snapshot 227
Table 130. Mylan NV: Revenue, 2017-2019, $ bn 228
Table 131. Novartis International AG: Company Snapshot 230
Table 132. Novartis International AG: Business Segmentation 230
Table 133. Novartis International AG: Revenue, 2017-2019, $ bn 231
Table 134. Pfizer Inc.: Company Snapshot 233
Table 135. Pfizer Inc.: Business Segmentation 234
Table 136. Pfizer Inc.: Product Portfolio 235
Table 137. Pfizer Inc.: Revenue, 2018-2020, $ bn 235
Table 138. Sanofi: Company Snapshot 238
Table 139. Sanofi: Business Segmentation 238
Table 140. Sanofi: Revenue, 2018-2020, $ bn 239
Table 141. Sun Pharmaceutical Industries Limited: Company Snapshot 241
Table 142. Teva Pharmaceutical Industries Ltd.: Company Snapshot 244
Table 143. Teva Pharmaceutical Industries Ltd.: Business Segmentation 245
Table 144. Thermo Fisher Scientific: Company Snapshot 246
Table 145. Risk Evaluation for Investing in Global Market, 2021-2028 249
Table 146. Critical Success Factors and Key Takeaways 252

List of Figures:

Figure 1. Research Method Flow Chart 16
Figure 2. Bottom-up Approach and Top-down Approach for Market Estimation 19
Figure 3. Global Market Forecast in Optimistic, Conservative and Balanced Perspectives, 2021-2028 21
Figure 4. Global Active Pharmaceutical Ingredients (API) Market, 2021-2028, $ bn 23
Figure 5. Impact of COVID-19 on Business 26
Figure 6. Primary Drivers and Impact Factors of Global Active Pharmaceutical Ingredients (API) Market 33
Figure 7. GDP per capita in the World, 1960-2018, $ thousand 36
Figure 8. Leading Causes of Death in the World, 2019-2020, million 37
Figure 9. Worldwide Geriatric Population (60 years and above) by Regions, 2015 & 2030, million 38
Figure 10. World Population 65 and Over, % of Total Population, 1950-2060 38
Figure 11. Primary Restraints and Impact Factors of Global Active Pharmaceutical Ingredients (API) Market 41
Figure 12. Investment Opportunity Analysis 45
Figure 13. Porter’s Fiver Forces Analysis of Global Active Pharmaceutical Ingredients (API) Market 48
Figure 14. Breakdown of Global Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, % of Revenue 52
Figure 15. Contribution to Global 2022-2028 Cumulative Revenue by Synthesis, Value ($ bn) and Share (%) 53
Figure 16. Global Active Pharmaceutical Ingredients (API) Market: Synthetic API, 2018-2028, $ bn 54
Figure 17. Global Active Pharmaceutical Ingredients (API) Market: Branded Synthetic API, 2018-2028, $ bn 55
Figure 18. Global Active Pharmaceutical Ingredients (API) Market: Generic Synthetic API, 2018-2028, $ bn 56
Figure 19. Global Active Pharmaceutical Ingredients (API) Market: Biotech API, 2018-2028, $ bn 57
Figure 20. Global Active Pharmaceutical Ingredients (API) Market: Monoclonal Antibodies, 2018-2028, $ bn 59
Figure 21. Global Active Pharmaceutical Ingredients (API) Market: Recombinant Proteins, 2018-2028, $ bn 60
Figure 22. Global Active Pharmaceutical Ingredients (API) Market: Vaccines, 2018-2028, $ bn 61
Figure 23. Global Active Pharmaceutical Ingredients (API) Market: Other Biotech APIs, 2018-2028, $ bn 62
Figure 24. Global Active Pharmaceutical Ingredients (API) Market: Innovative Biologic API, 2018-2028, $ bn 64
Figure 25. Global Active Pharmaceutical Ingredients (API) Market: Generic Biosimilar API, 2018-2028, $ bn 65
Figure 26. Global Active Pharmaceutical Ingredients (API) Market: Mammalian Expression, 2018-2028, $ bn 67
Figure 27. Global Active Pharmaceutical Ingredients (API) Market: Microbial Expression, 2018-2028, $ bn 68
Figure 28. Global Active Pharmaceutical Ingredients (API) Market: Yeast Expression, 2018-2028, $ bn 69
Figure 29. Global Active Pharmaceutical Ingredients (API) Market: Insect Expression, 2018-2028, $ bn 70
Figure 30. Global Active Pharmaceutical Ingredients (API) Market: Other Expression Technologies, 2018-2028, $ bn 71
Figure 31. Global Active Pharmaceutical Ingredients (API) Market: HPAPI, 2018-2028, $ bn 72
Figure 32. Global Active Pharmaceutical Ingredients (API) Market: Branded HPAPI, 2018-2028, $ bn 73
Figure 33. Global Active Pharmaceutical Ingredients (API) Market: Generic HPAPI, 2018-2028, $ bn 74
Figure 34. Breakdown of Global Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, % of Revenue 75
Figure 35. Contribution to Global 2022-2028 Cumulative Revenue by Manufacturing Process, Value ($ bn) and Share (%) 76
Figure 36. Global Active Pharmaceutical Ingredients (API) Market: Captive Manufacturing, 2018-2028, $ bn 77
Figure 37. Global Active Pharmaceutical Ingredients (API) Market: Branded Captive API, 2018-2028, $ bn 78
Figure 38. Global Active Pharmaceutical Ingredients (API) Market: Generic Captive API, 2018-2028, $ bn 79
Figure 39. Global Active Pharmaceutical Ingredients (API) Market: Merchant Manufacturing, 2018-2028, $ bn 80
Figure 40. Global Active Pharmaceutical Ingredients (API) Market: Branded Merchant API, 2018-2028, $ bn 82
Figure 41. Global Active Pharmaceutical Ingredients (API) Market: Generic Merchant API, 2018-2028, $ bn 83
Figure 42. Global Active Pharmaceutical Ingredients (API) Market: Merchant Synthetic API, 2018-2028, $ bn 85
Figure 43. Global Active Pharmaceutical Ingredients (API) Market: Merchant Biotech API, 2018-2028, $ bn 86
Figure 44. Breakdown of Global Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, % of Revenue 87
Figure 45. Contribution to Global 2022-2028 Cumulative Revenue by Therapeutic Application, Value ($ bn) and Share (%) 88
Figure 46. Global Active Pharmaceutical Ingredients (API) Market: Infectious Diseases, 2018-2028, $ bn 89
Figure 47. Global Active Pharmaceutical Ingredients (API) Market: Oncology, 2018-2028, $ bn 90
Figure 48. Global Active Pharmaceutical Ingredients (API) Market: Ophthalmology , 2018-2028, $ bn 91
Figure 49. Global Active Pharmaceutical Ingredients (API) Market: Cardiovascular Disorders, 2018-2028, $ bn 92
Figure 50. Global Active Pharmaceutical Ingredients (API) Market: Central Nervous System, 2018-2028, $ bn 93
Figure 51. Global Active Pharmaceutical Ingredients (API) Market: Pulmonary Disorders, 2018-2028, $ bn 94
Figure 52. Global Active Pharmaceutical Ingredients (API) Market: Orthopedics, 2018-2028, $ bn 95
Figure 53. Global Active Pharmaceutical Ingredients (API) Market: Other Applications, 2018-2028, $ bn 96
Figure 54. Breakdown of Global Active Pharmaceutical Ingredients (API) Market by Drug Type, 2018-2028, % of Revenue 97
Figure 55. Contribution to Global 2022-2028 Cumulative Revenue by Drug Type, Value ($ bn) and Share (%) 98
Figure 56. Global Active Pharmaceutical Ingredients (API) Market: Branded Prescription Drugs, 2018-2028, $ bn 99
Figure 57. Global Active Pharmaceutical Ingredients (API) Market: Generic Prescription Drugs, 2018-2028, $ bn 100
Figure 58. Global Active Pharmaceutical Ingredients (API) Market: OTC Drugs, 2018-2028, $ bn 101
Figure 59. Global Market Snapshot by Region 102
Figure 60. Geographic Spread of Worldwide Active Pharmaceutical Ingredients (API) Market, 2018-2028, % of Revenue 103
Figure 61. Contribution to Global 2022-2028 Cumulative Revenue by Region, Value ($ bn) and Share (%) 104
Figure 62. North American Active Pharmaceutical Ingredients (API) Market, 2018-2028, $ bn 108
Figure 63. Breakdown of North America Active Pharmaceutical Ingredients (API) Market by Country, 2021 and 2028, % of Revenue 108
Figure 64. Contribution to North America 2022-2028 Cumulative Revenue by Country, Value ($ bn) and Share (%) 109
Figure 65. U.S. Active Pharmaceutical Ingredients (API) Market, 2018-2028, $ bn 111
Figure 66. Manufacturing Sites of APIs for U.S. Market by Country or Region, 117
Figure 67. Number and Percentage of API Facilities for the 370 U.S. Marketed Drugs on the 2019 WHO Essential Medicines List 117
Figure 68. Number and Percentage of API Facilities for the 370 U.S. Marketed Drugs on the 2019 WHO Essential Medicines List 118
Figure 69. Canada Active Pharmaceutical Ingredients (API) Market, 2018-2028, $ bn 121
Figure 70. Active Pharmaceutical Ingredients (API) Market in Mexico, 2018-2028, $ bn 123
Figure 71. European Active Pharmaceutical Ingredients (API) Market, 2018-2028, $ bn 126
Figure 72. Breakdown of European Active Pharmaceutical Ingredients (API) Market by Country, 2021 and 2028, % of Revenue 126
Figure 73. Contribution to Europe 2022-2028 Cumulative Revenue by Country, Value ($ bn) and Share (%) 127
Figure 74. Active Pharmaceutical Ingredients (API) Market in UK, 2018-2028, $ bn 128
Figure 75. Active Pharmaceutical Ingredients (API) Market in France, 2018-2028, $ bn 130
Figure 76. Active Pharmaceutical Ingredients (API) Market in Germany, 2018-2028, $ bn 132
Figure 77. Active Pharmaceutical Ingredients (API) Market in Spain, 2018-2028, $ bn 134
Figure 78. Active Pharmaceutical Ingredients (API) Market in Italy, 2018-2028, $ bn 136
Figure 79. Active Pharmaceutical Ingredients (API) Market in Russia, 2018-2028, $ bn 138
Figure 80. Active Pharmaceutical Ingredients (API) Market in Rest of Europe, 2018-2028, $ bn 140
Figure 81. Asia-Pacific Active Pharmaceutical Ingredients (API) Market, 2018-2028, $ bn 143
Figure 82. Breakdown of APAC Active Pharmaceutical Ingredients (API) Market by Country, 2021 and 2028, % of Revenue 143
Figure 83. Contribution to APAC 2022-2028 Cumulative Revenue by Country, Value ($ bn) and Share (%) 144
Figure 84. Active Pharmaceutical Ingredients (API) Market in China, 2018-2028, $ bn 145
Figure 85. Active Pharmaceutical Ingredients (API) Market in Japan, 2018-2028, $ bn 148
Figure 86. Active Pharmaceutical Ingredients (API) Market in India, 2018-2028, $ bn 150
Figure 87. Active Pharmaceutical Ingredients (API) Market in Australia, 2018-2028, $ bn 152
Figure 88. Active Pharmaceutical Ingredients (API) Market in South Korea, 2018-2028, $ bn 154
Figure 89. Active Pharmaceutical Ingredients (API) Market in Rest of APAC, 2018-2028, $ bn 156
Figure 90. South America Active Pharmaceutical Ingredients (API) Market, 2018-2028, $ bn 159
Figure 91. Breakdown of South America Active Pharmaceutical Ingredients (API) Market by Country, 2021 and 2028, % of Revenue 159
Figure 92. Contribution to South America 2022-2028 Cumulative Revenue by Country, Value ($ bn) and Share (%) 160
Figure 93. Active Pharmaceutical Ingredients (API) Market in Argentina, 2018-2028, $ bn 161
Figure 94. Active Pharmaceutical Ingredients (API) Market in Brazil, 2018-2028, $ bn 163
Figure 95. Active Pharmaceutical Ingredients (API) Market in Chile, 2018-2028, $ bn 165
Figure 96. Active Pharmaceutical Ingredients (API) Market in Rest of South America, 2018-2028, $ bn 167
Figure 97. Active Pharmaceutical Ingredients (API) Market in Rest of the World (RoW), 2018-2028, $ bn 169
Figure 98. Breakdown of RoW Active Pharmaceutical Ingredients (API) Market by Country, 2021 and 2028, % of Revenue 169
Figure 99. Contribution to RoW 2022-2028 Cumulative Revenue by Country, Value ($ bn) and Share (%) 170
Figure 100. Active Pharmaceutical Ingredients (API) Market in UAE, 2018-2028, $ bn 171
Figure 101. Active Pharmaceutical Ingredients (API) Market in Saudi Arabia, 2018-2028, $ bn 173
Figure 102. Active Pharmaceutical Ingredients (API) Market in South Africa, 2018-2028, $ bn 175
Figure 103. Growth Stage of Global Active Pharmaceutical Ingredients (API) Industry over the Forecast Period 178
Figure 104. Top products of AstraZeneca based on revenue from 2016 to 2019 (in million U.S. dollars) 185

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Global Active Pharmaceutical Ingredients (API) Market 2021-2028

Global Active Pharmaceutical Ingredients (API) Market 2021-2028